1. Whether the presumption of mens rea only applies to elements that criminalize otherwise innocent conduct or instead also applies to elements that increase statutory minimum and maximum penalties.

2. Whether a knowingly or recklessly mens rea applies to the elements of drug type and quantity establishing mandatory minimum and enhanced maximum sentences under 21 U.S.C. § 841.

Whether the presumption of mens rea applies to elements that increase statutory minimum and maximum penalties or only to elements that criminalize otherwise innocent conduct