1) Whether preemption is a threshold and defining consideration that the lower courts must consider in determining whether a claimed invention is directed to patent eligible subject matter under Section 101, and

2) Whether the courts below have erred in conflating the Step Two conventionality analysis of Alice with the factual prior art patentability analysis of Section 103, without the evidentiary opportunities and protections against hindsight bias afforded by Section 103 and in conflict with this Court's precedent in Graham v. John Deere Co. of Kansas City, 383 U.S. 1 (1966).

Whether preemption is a threshold and defining consideration that the lower courts must consider in determining whether a claimed invention is directed to patent-eligible subject matter under Section 101