1. Whether application of the deadline for filing a Notice of Appeal under the Federal Rules of Appellate Procedure violates the appellant's right to counsel under the Sixth Amendment, when the failure to file a timely appeal was caused by counsel's failure to file in violation of the appellant's right to effective assistance of counsel under this Court's decision in Roe v. Flores-Ortega, 528 U.S. 470 (2000).

2. Whether the causation requirement for the application of the statutory sentence enhancement under 21 U.S.C. § 841(b)(1)(c) is not satisfied when the toxicology evidence shows that the cause of injury or death was lethal levels of two drugs, only one of which was connected with the defendant.

Whether application of the deadline for filing a Notice of Appeal under the Federal Rules of Appellate Procedure violates the appellant's right to counsel under the Sixth Amendment